The
report " PharmaPoint: Methicillin-Resistant Staphylococcus
Aureus (MRSA) - Global Drug Forecast and Market Analysis to 2024 ",
has been prepared based on an in-depth market analysis with inputs
from industry experts.
With
the discovery of penicillin, the first naturally-occurring
antibiotic, in 1928, and its mass production in the early 1940s,
infections with Staphylococcus aureus were mostly treatable, without
any major complications. However, clinicians soon observed the
emergence of penicillin-resistant strains of S. aureus, which was
largely driven by bacterial expression of beta-lactamases.
Methicillin, a novel penicillin analogue that was resistant to
beta-lactamases, was introduced in 1959, and was initially effective
against penicillin-resistant S. aureus strains. However, this success
was short-lived, as the first methicillin-resistant S. aureus (MRSA)
strain had been identified in the lab by 1961, and cases of MRSA were
first observed in the clinic in 1968. Initially, MRSA strains only
occurred in small and local outbreaks across the US and Europe, but
they can now be found around the world.
Today,
the MRSA market is highly competitive, as physicians have a myriad of
antimicrobial agents at their disposal that are approved to treat
these severe and often life-threatening infections. There are
currently over 10 marketed antibiotics that have demonstrated potent
activity against MRSA, which are frequently used to treat invasive
infections in the hospital setting. GlobalData projects the global
MRSA marketplace - which, for the purposes of this report, includes
patients hospitalized with MRSA skin infections, pneumonia, or
bacteremia in the seven major pharmaceutical markets (7MM; US,
France, Germany, Italy, Spain, UK, Japan) - to experience limited
growth from 2014-2024.
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Highlights
Key
Questions Answered
- How will the MRSA therapeutics market landscape in the 7MM (US, France, Germany, Italy, Spain, UK, Japan) change from 2014-2024?
- What are the most promising late-stage pipeline drugs for MRSA?
- How do the clinical and commercial attributes of late-stage pipeline therapies compare with one another, and against existing treatment options?
- What are the key unmet needs in MRSA treatment landscape?
- What drivers and barriers will influence MRSA therapeutics sales in the 7MM over the forecast period?
Key
Findings
- The global MRSA marketplace, which, for the purposes of this report, includes patients hospitalized with MRSA skin infections, pneumonia, or bacteremia in the 7MM, was worth approximately $1.40 billion in 2014. GlobalData projects the market to exceed $1.45 billion in sales by 2024, at a Compound Annual Growth Rate (CAGR) of 0.4% from 2014-2024. These sales are projected to originate predominantly from the US (with a 71% market share), followed distantly by Japan (with a 16% market share).
- The recent and expected launches of novel antimicrobial agents with potent activity against MRSA, led by Allergans Dalvance (dalbavancin), Mercks Sivextro (tedizolid phosphate), The Medicines Companys Orbactiv (oritavancin), Debiopharms Debio1450, and Nabrivas lefamulin, will be a principal driver of MRSA drug sales growth across the 7MM from 2014-2014.
- Competition from generics manufacturers, spurred on by the anticipated loss of patent protection for the market leaders Zyvox (linezolid) and Cubicin (daptomycin), will serve as a formidable barrier to growth for the duration of the forecast period.
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Sample copy of this Report @
Scope
- Overview of MRSA infections, including epidemiology, etiology, pathophysiology, symptoms, diagnosis, and current management strategies.
- Topline MRSA market revenue from 2014-2024. Annual cost of therapy (ACOT) and major pipeline product sales in this forecast period are included.
- Key topics covered include current treatment options, unmet needs and opportunities, and the drivers and barriers affecting MRSA therapeutics sales in the 7MM.
- Pipeline analysis: comprehensive data split across different phases, emerging novel trends under development, synopses of innovative early-stage projects, and detailed analysis of late-stage pipeline products.
- Analysis of the current and future market competition in the global MRSA therapeutics market. Insightful review of the key industry drivers, restraints and challenges. Each trend is independently researched to provide qualitative analysis of its implications.
Reasons
to buy
The
report will enable you to -
- Develop and design your in-licensing and out-licensing strategies through a review of pipeline products and technologies, and by identifying the companies with the most robust pipeline.
- Develop business strategies by understanding the trends shaping and driving the global MRSA therapeutics market.
- Drive revenues by understanding the key trends, innovative products and technologies, market segments, and companies likely to impact the MRSA therapeutics market in the future.
- Formulate effective sales and marketing strategies by understanding the competitive landscape and by analyzing the performance of various competitors.
- Identify emerging players with potentially strong product portfolios and create effective counter-strategies to gain a competitive advantage.
- Organize your sales and marketing efforts by identifying the market categories and segments that present maximum opportunities for consolidations, investments, and strategic partnerships.
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Table
of Content :
1
Table of Contents 11
1.1
List of Tables 17
1.2
List of Figures 23
2
Introduction 25
2.1
Catalyst 25
2.2
Related Reports 26
2.3
Upcoming Related Reports 27
3
Disease Overview 28
3.1
Etiology 28
3.1.1
MRSA Strains 31
3.1.2
VISA Strains 33
3.1.3
VRSA Strains 33
3.2
Pathophysiology 34
3.2.1
Infection Sites 34
3.2.2
Expression of Virulence Factors 36
3.2.3
Mechanisms of Antibiotic Resistance 38
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