"The
Report Complete 2013-14 Induced Pluripotent Stem Cell (iPSC) Industry
Report provides information on pricing, market analysis, shares,
forecast, and company profiles for key industry participants. -
MarketResearchReports.biz"
Stem cell research and
experimentation has been in process for well over five decades, as
stem cells have the unique ability to divide and replicate
repeatedly. In addition, their “unspecialized” nature allows them
to differentiate into a wide variety of specialized cell types. The
possibilities arising from these characteristics have caused great
commercial interest, with potential applications ranging from the use
of stem cells in reversal or treatment of disease, to targeted cell
therapy, tissue regeneration, pharmacological testing on
cell-specific tissues, and more. Diseases such as Huntington’s
Chorea, Parkinson’s Disease, and spinal cord injuries are examples
of clinical applications in which stem cells could offer benefits in
halting or even reversing damage.
Traditionally, scientists have
worked with both embryonic and adult stem cells as research tools.
While the appeal of embryonic cells has been their ability to
differentiate into any type of cell, there has been significant
ethical, moral and spiritual controversy surrounding their use for
research purposes. Although some adult stem cells do have
differentiation capacity, it is often limited in nature, which
creates narrow options for use. Thus, induced pluripotent stem cells
represent a promising combination of adult and embryonic stem cell
characteristics.
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Discovery:
Groundbreaking experimentation
in 2006 led to the introduction of induced pluripotent stem cells
(iPSC). These are adult cells which are isolated and then transformed
into embryonic-like stem cells through the manipulation of gene
expression, as well as other methods. Research and experimentation
using mouse cells at Kyoto University in Japan was the first instance
in which there was successful generation of the iPSC. In 2007, a
series of follow-up experiments were done at Kyoto University in
which human adult cells were transformed into iPSC cells.
While there has been continued
excitement at the prospect of what such artificially re-manufactured
cells could contribute to medical advances, there have also been
issues along the way. By 2010, there were a number of private
companies that were ready to capitalize on the breakthrough
technology that iPSCs represent. One such company, Advanced Cell
Technology in Worcester, Massachusetts, discovered several
problematic issues while conducting experiments for the purpose of
applying for U.S. Food and Drug Administration approval to use iPSCs
in therapeutic applications. Concerns such as premature cell death,
mutation into cancer cells, and low proliferation rates were some of
the problems that surfaced.
Research Advances:
Continued research and
experimentation has resulted in numerous advances over the last few
years. In one example, the University of Michigan announced in
“Circulation Research” (2012) that they had developed innovative
methods for use of induced pluripotent stem cells derived from skin
biopsies to create cardiac muscle cells. This accomplishment quickly
fueled other research into the use of iPSCs for the reversal and
repair of diseased heart tissue.
Similar advances will continue
to be perfected for use of reprogrammed adult cells in the treatment
of other diseases and disorders. Original techniques for iPSC
production, such as viral induced transcription processes, are being
replaced with newer technologies as private industries join with the
scientific community to develop safe and efficient methods of iPSC
production. With sustained research and experimentation, established
guidelines for effective production of iPSCs will be commonplace.
In summary, induced pluripotent
stem cells represent a promising tool for use in the reversal and
repair of many previously incurable diseases.
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Market Metrics - iPSC
Research Products:
For this reason a large and
thriving research products market has grown into existence for the
cell type. The number of iPSC research products sold worldwide has
been growing at an annual rate of 14.7% for the past five years. In
addition, 22% of all stem cell researchers now self-report as having
used induced pluripotent stem cells within a research project. It is
clear that iPSCs are a vital research trend within the scientific
community.
A distinctive feature of this
report is an end-user survey of 274 researchers (131 U.S. / 143
International) that identify as having induced pluripotent stem cells
as their core research focus. These survey findings reveal iPSC
researcher needs, technical preferences, key factors influencing
buying decisions, and more. They can be used to make effective
product development decisions, create targeted marketing messages,
and produce higher prospect-to-client conversion rates.
Remember, to benefit from
this lucrative product market, you need to anticipate and serve the
needs of your clients, or your competitors will.
Key Findings Include:
- Charts, Timelines, and Financials for the iPSC Research Product Market
- Trends for iPSC Grants, Scientific Publications, and Patents
- 5-Year Market Size Projections (2014-2018)
- Competitive Environment Analysis, including Market Share by Competitor
- Preferred Species for iPSC Research
- iPSC Product Categories (Breakdown of Market Share by Each)
- Consumer Behavioral Patterns and Preferred Providers
- Crucial Trends and Unmet Market Needs
- “Tested Sentences” for Selling to iPSC Scientists
- Breakdown of the Marketing Methods Used by Industry Participants
- End-User Survey of iPSC Researchers (131 U.S. / 143 International)
Table
Of Content
I.
ABSTRACT
II.
BACKGROUND
A.
Definition
B.
Discovery
C.
Advantages & Disadvantages
III.
TIMELINE
A.
Production of iPSCs (Key Events)
B.
Full Timeline of Events
IV.
RESEARCH APPLICATIONS
A.
Pharmaco-Toxicological Screening
B.
Disease Modeling
C.
Autologous Cell Transplantation
D.
Breakdown of iPSC Research, By Applied Research Application
V.
CHARACTERIZATION OF iPSC RESEARCH ADVANCES
A.
Methods of Making iPSCs – Comparison of Methods by Downstream
Application
B.
Summary of iPSC Derivation Methods, by Cell Type
C.
Diseases in Which iSPCs Have Been Derived from Patients
VI.
COMPANIES SELLING iPSC RESEARCH PRODUCTS
A.
List of Companies
B.
Rate of Entrants by Year
VII.
TYPES OF iPSC RESEARCH PRODUCTS
A.
Stem Cell Product Categories
B.
iPSC Market Share Breakdown, By Product Area
VIII.
COMPANIES DEVELOPING iPSC THERAPIES
A.
Commerical Entities
1.
ViaCyte
2.
Fate Therapeutic
3.
iPerian
4.
Cellular Dynamics
5.
Mesoblast
B.
Non-Commercial Organizations Developing iPSC Therapies
IX.
STRATEGIC COLLABORATIONS FOR DEVELOPMENT OF iPSC PRODUCTS
A.
Life Technologies
B.
Lonza Group AG
C.
EMD Millipore
D.
Sigma Aldrich
E.
Roslin Cells, Ltd.
F.
ArunA Biomedical
G.
CeeTox and Cellular Dynamics
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