"The
Report Stem Cell Research Products - Opportunities, Tools, and
Technologies 2016 provides information on pricing, market analysis,
shares, forecast, and company profiles for key industry participants.
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Claim
this global strategic report to understand unique product
opportunities by stem cell type, derive more revenue from products
sold to stem cell scientists, and identify new product development
opportunities before the competition. Use the “Survey of Stem Cell
Scientists” to understand technical requirements, unmet needs, and
purchasing preferences of stem cell researchers worldwide.
This
report explores unique market opportunities by stem cell type,
including mesenchymal stem cells, hematopoietic stem cells, induced
pluripotent stem cells, embryonic stem cells, neural stem cells, and
more.
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The Market for Stem Cell
Research Products
Stem
cells are primitive cells found in all multi-cellular organisms that
are characterized by self-renewal and the capacity to differentiate
into any mature cell type. Several broad categories of stem cells
exist, including:
- Embryonic stem cells, derived from blastocysts
- Perinatal stem cells, obtained during the period immediately before and after birth
- Adult stem cells, found in adult tissues
- Induced pluripotent stem cells, produced by genetically reprogramming adults cells
- Cancer stem cells, which give rise to clonal populations of cells that form tumors or disperse in the body
Stem
cell research and experimentation have been in process for well over
five decades, as stem cells have the unique ability to divide and
replicate repeatedly. In addition, their “unspecialized” nature
allows them to differentiate into a wide variety of specialized cell
types.
In
a developing embryo, stem cells can differentiate into all of the
specialized embryonic tissues. In adult organisms, stem and
progenitor cells act as a repair system for the body, replenishing
specialized cells.
Traditionally,
scientists have worked with both embryonic and adult stem cells as
research tools. While the appeal of embryonic cells has been their
ability to differentiate into any type of cell, there has been
significant ethical, moral and spiritual controversy surrounding
their use for research purposes. Although some adult stem cells do
have differentiation capacity, it is often limited in nature, which
results in fewer options for use.
Thus,
when induced pluripotent stem cells (iPSCs) were produced from mouse
cells in 2006 by Shinya Yamanaka of Kyoto University in Japan, they
represented a promising combination of adult and embryonic stem cell
characteristics. By 2007, a series of follow-up experiments were done
at Kyoto University in which human adult cells were transformed into
iPSC cells. Nearly simultaneously, a research group led by James
Thomson at the University of Wisconsin-Madison accomplished the same
feat of deriving iPSC lines from human somatic cells.
The
possibilities arising from these characteristics have resulted in
great commercial interest, with potential applications ranging from
the use of stem cells in reversal and treatment of disease, to
targeted cell therapy, tissue regeneration, pharmacological testing
on cell-specific tissues, and more. Huntington’s disease,
Parkinson’s disease, and spinal cord injuries are examples of
conditions for which clinical applications involving stem cells could
offer benefits in halting or even reversing adverse effects.
Also
of interest to clinical researchers is the potential to use stem
cells in regenerative medicine. Additionally, the ability to use stem
cells to improve drug target validation and toxicology screening is
of intense interest to the pharmaceutical industry.
At this time, the following
account for the majority of stem cell research:
- Basic Research – Understanding stem cell mechanisms and behavior
- Regenerative Medicine – Reversal of injury or disease
- Drug Target Validation and Drug Delivery – Treatment of disease
- Toxicology Screening – Drug safety and efficacy assessment
- To facilitate research resulting from interest in these potential far-ranging applications, a large and growing stem cells research products market has emerged.
Large companies selling stem
cell research products include:
Thermo Fisher Scientific
- BD Biosciences, a Division of Becton Dickinson
- Merck KGaA
- Miltenyi Biotec
- STEMCELL Technologies
- Lonza Group
- Clontech (a Takara Bio Company)
- GE Healthcare Life Sciences.
While several of these dominant
market players have utilized acquisition strategies to grow and
capture market share, Merck KGaA has had a particularly strong
commitment to this approach, acquiring several other massive major
players within the stem cell research products marketplace, including
Milllipore on February 26, 2010, for $7.2 billion, and Sigma-Aldrich
on September 22, 2014, for $17 billion. Dozens of mid-sized suppliers
of stem cell research products also exist, as well as over 100 small
specialty providers.
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Currently, the following
compose the majority of stem cell research product sales worldwide:
Primary antibodies to stem
cell antigens
Bead-based stem cell
separation systems
Fluorescent-based labeling
and detection
Stem cell protein
purification and analysis tools
Tools for DNA and RNA-based
characterization of stem cells
Isolation/characterization
services
Stem cell culture media and
reagents
Stem cell specific growth
factors and cytokines
Tools for stem cell gene
regulation
Stem cell services and
mechanisms for in vivo and in vitro stem cell tracking
Expansion/differentiation
services for stem cell media and RNAi
Stem cell lines
Currently, mesenchymal stem
cells (MSCs) are one of the fastest growing areas of stem cell
research, with more than 25,000 scientific publications published
about the cell type and more than 400 clinical trials underway
worldwide. Importantly, 2015 was the first year in history that
mesenchymal stem cells surpassed hematopoietic stem cells (HSCs) for
the most scientific publications of any stem cell type. In addition,
Google Trend data shows MSC searches to be approximately twice as
common as the next most popular stem cell type.
MSCs also being explored for
use in 3D printing applications, because of their unique capacity to
form structural tissues. In particular, there will be a demand for
companies to supply MSC populations for use in 3D printing inks.
Induced pluripotent stem cells
(iPSCs) are also an interesting area of stem cell research, with
Japan committing to being a market leader in this area. In the past
year, Japan has accelerated its position as a hub for regenerative
medicine research, largely driven by support from Prime Minister
Shinzo Abe who has identified regenerative medicine and cellular
therapy as key to the Japan’s strategy to drive economic growth.
The Prime Minister has
encouraged a growing range of collaborations between private industry
and academic partners through an innovative legal framework. Most
importantly to the stem cell research products marketplace, Japan’s
Education Ministry said it is planning to spend 110 billion yen
($1.13 billion) on induced pluripotent stem cell research during the
next 10 years, and the Japanese parliament has been discussing bills
that would “speed the approval process and ensure the safety of
such treatments.”
Utilization of other stem cell
types in research settings continue as well, with hematopoietic stem
cells being explored for their broad therapeutic applications, neural
stem cells being explored for their ability to address unmet medical
needs, and adipose-derived stem cells catching the interest of the
research community because of the increasing prevalence of orthopedic
doctors who are using these cells for musculoskelal applications, an
area that the FDA has begun to tightly regulate.
Key report findings include:
- Market size determinations, with 5-year projections for the stem cell research products market (2016-2020)
- Year-over-year analysis of stem cell grant rates, patent rates, clinical trial rates, and scientific publication rates
- Stem cell funding sources, trends, and amounts (domestic and international)
- Stem cell research applications, including priorities by segment
- Relative demand for stem cell products, by stem cell type
- Breakdown of stem cell product categories
- Competitive analysis of leading stem cell research product companies
- Online trends for stem cells, including Google Trends and Google Adwords
- Social analytics for stem cells, including activity on Twitter, LinkedIn, Facebook, and more
- Communications strategies for accessing the marketplace
- End-user survey of stem cell scientists
Competing within the stem cell
marketplace can involve complicated and confusing decisions, but it
doesn’t have to. Claim this report to reveal the current and future
needs of your customer base, so you can focus your marketing efforts
on profitable products, in promising research areas, within lucrative
markets.
Input Sources
- The content and statistics contained in this report were compiled using a broad range of sources. These input sources include:
- Stem Cell Grant Funding Database (RePORT Database, CIRM, MRC, Wellcome Trust - UK)
- Stem Cell Patent Database (United States Patent and Trade Office, World Intellectual Property Organization)
- Stem Cell Clinical Trial Database (ClinicalTrials.gov, International Clinical Trials Registry Platform, European Union Clinical Trials Register )
- Stem Cell Scientific Publication Database (PubMed, Highwire Press, Google Scholar)
- Stem Cell Product Launch Announcements (Trade Journals, Google News)
- Stem Cell Industry Events (Google News, Google Alerts)
- Stem Cell Company News (SEC Filings, Investor Publications, Historic Performance)
- nternational Surveys (Electronically Distributed End-User Surveys)
And More
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